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복잡계 자기조립 연구단
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Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbit[6]uril Derivatives

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Title
Highly Sensitive and Selective Biosensors Based on Organic Transistors Functionalized with Cucurbit[6]uril Derivatives
Author(s)
Jang M.; Kim H.; Lee S.; Hyun Woo Kim; Jayshree K. Khedkar; Young Min Rhee; Ilha Hwang; Kimoon Kim; Oh J.H.
Publication Date
2015-08
Journal
ADVANCED FUNCTIONAL MATERIALS, v.25, no.30, pp.4882 - 4888
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Biosensors based on a field-effect transistor platform allow continuous monitoring of biologically active species with high sensitivity due to the amplification capability of detected signals. To date, a large number of sensors for biogenic substances have used high-cost enzyme immobilization methods. Here, highly sensitive organic field-effect transistor (OFET)-based sensors functionalized with synthetic receptors are reported that can selectively detect acetylcholine (ACh+), a critical ion related to the delivery of neural stimulation. A cucurbit[6]uril (CB[6]) derivative, perallyloxyCB[6] ((allyloxy)12CB[6], AOCB[6]), which is soluble in methanol but insoluble in water, has been solution-deposited as a selective sensing layer onto a water-stable p-channel semiconductor, 5,5′-bis-(7-dodecyl-9H-fluoren-2-yl)-2,2′-bithiophene layer. The OFET-based sensors exhibit a detection limit down to 1 × 10-12 m of ACh+, which is six orders of magnitude lower than that of ion-selective electrode-based sensors. Moreover, these OFET-based sensors show highly selective discrimination of ACh+ over choline (Ch+). The findings demonstrate a viable method for the fabrication of OFET-based biosensors with high sensitivity and selectivity, and allow for practical applications of OFETs as high-performance sensors for biogenic substances. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/1941
ISSN
1616-301X
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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