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면역미생물공생연구단
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TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

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Title
TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders
Author(s)
Chun-Pyo Hong; Chang Ho Yun; Lee GW; Park A; Kim YM; Myoung Ho Jang
Publication Date
2015-11
Journal
OBESITY, v.23, no.11, pp.2199 - 2206
Publisher
NATURE PUBLISHING GROUP
Abstract
Objective: Recent studies have revealed a link between Toll-like receptor (TLR) signaling and the adipose tissue inflammation associated with obesity. Although TLR9 is known to play an important role in inflammation and innate immunity, its role in mediating adipose tissue inflammation has not yet been investigated. Thus, the objective of this study was to determine the role of TLR9 in regulating immune cells in visceral adipose tissue and maintaining the metabolic homeostasis. Methods: Wild-type and TLR9-deficient mice were fed with a high-fat diet, and the body weight gain, glucose tolerance, insulin sensitivity, and adipose tissue inflammation were examined. Results: TLR9-deficient mice gained significantly more weight and body fat under a high-fat diet than wild-type mice and exhibited more severe glucose intolerance and insulin resistance. We also found a dramatic increase of M1 macrophages as well as TH1 cells in the adipose tissue of TLR9-deficient mice compared to wild-type mice. Furthermore, the levels of various proinflammatory cytokines and chemokines were higher in TLR9-deficient mice. Conclusions: TLR9 signaling i
URI
https://pr.ibs.re.kr/handle/8788114/1848
ISSN
1930-7381
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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