Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites

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Title
Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites
Author(s)
Jeongbin Park; Sangsu Bae; Jin Soo Kim
Publication Date
2015-12
Journal
BIOINFORMATICS, v.31, no.24, pp.4014 - 4016
Publisher
OXFORD UNIV PRESS
Abstract
We present Cas-Designer, a user-friendly program to aid researchers in choosing appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided endonucleases, which are now widely used for biomedical research and biotechnology. Cas-Designer rapidly provides the list of all possible guide RNA sequences in a given input DNA sequence and their potential off-target sites including bulge-type sites in a genome of choice. In addition, the program assigns an out-of-frame score to each target site to help users choose appropriate sites for gene knockout. Cas-Designer shows the results in an interactive table and provides user-friendly filter functions.
URI
https://pr.ibs.re.kr/handle/8788114/1822
ISSN
1367-4803
Appears in Collections:
Center for Genome Engineering(유전체 교정 연구단) > Journal Papers (저널논문)
Files in This Item:
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