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Integrated platform for multiscale molecular imaging and phenotyping of the human brain

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Title
Integrated platform for multiscale molecular imaging and phenotyping of the human brain
Author(s)
Juhyuk Park; Ji Wang; Webster Guan; Lars A. Gjesteby; Dylan Pollack; Lee Kamentsky; Nicholas B. Evans; Jeff Stirman; Xinyi Gu; Chuanxi Zhao; Slayton Marx; Minyoung E. Kim; Seo Woo Choi; Michael Snyder; David Chavez; Clover Su-Arcaro; Yuxuan Tian; Chang Sin Park; Qiangge Zhang; Dae Hee Yun; Mira Moukheiber; Guoping Feng; X William Yang; C Dirk Keene; Patrick R. Hof; Satrajit S. Ghosh; Matthew P. Frosch; Laura J. Brattain; Kwanghun Chung
Publication Date
2024-06
Journal
Science, v.384, no.6701
Publisher
American Association for the Advancement of Science
Abstract
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ-scale system. We developed a platform that simultaneously extracts spatial, molecular, morphological, and connectivity information of individual cells from the same human brain. The platform includes three core elements: a vibrating microtome for ultraprecision slicing of large-scale tissues without losing cellular connectivity (MEGAtome), a polymer hydrogel-based tissue processing technology for multiplexed multiscale imaging of human organ-scale tissues (mELAST), and a computational pipeline for reconstructing three-dimensional connectivity across multiple brain slabs (UNSLICE). We applied this platform for analyzing human Alzheimer's disease pathology at multiple scales and demonstrating scalable neural connectivity mapping in the human brain.
URI
https://pr.ibs.re.kr/handle/8788114/15390
DOI
10.1126/science.adh9979
ISSN
0036-8075
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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