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A magnetically powered nanomachine with a DNA clutch

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Title
A magnetically powered nanomachine with a DNA clutch
Author(s)
Mouhong Lin; Jung-Uk Lee; Youngjoo Kim; Gooreum Kim; Yunmin Jung; Ala Jo; Mansoo Park; Sol Lee; Jungsu David Lah; Jongseong Park; Kunwoo Noh; Jae-Hyun Lee; Minsuk Kwak; Dominik Lungerich; Jinwoo Cheon
Publication Date
2024-05
Journal
Nature Nanotechnology, v.19, pp.646 - 651
Publisher
Nature Publishing Group
Abstract
Machines found in nature and human-made machines share common components, such as an engine, and an output element, such as a rotor, linked by a clutch. This clutch, as seen in biological structures such as dynein, myosin or bacterial flagellar motors, allows for temporary disengagement of the moving parts from the running engine. However, such sophistication is still challenging to achieve in artificial nanomachines. Here we present a spherical rotary nanomotor with a reversible clutch system based on precise molecular recognition of built-in DNA strands. The clutch couples and decouples the engine from the machine’s rotor in response to encoded inputs such as DNA or RNA. The nanomotor comprises a porous nanocage as a spherical rotor to confine the magnetic engine particle within the nanospace (∼0.004 μm3) of the cage. Thus, the entropically driven irreversible disintegration of the magnetic engine and the spherical rotor during the disengagement process is eliminated, and an exchange of microenvironmental inputs is possible through the nanopores. Our motor is only 200 nm in size and the clutch-mediated force transmission powered by an embedded ferromagnetic nanocrystal is high enough (∼15.5 pN at 50 mT) for the in vitro mechanical activation of Notch and integrin receptors, demonstrating its potential as nano-bio machinery. © The Author(s), under exclusive licence to Springer Nature Limited 2024.
URI
https://pr.ibs.re.kr/handle/8788114/15210
DOI
10.1038/s41565-023-01599-6
ISSN
1748-3387
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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