BROWSE

Related Scientist

kim,seonggi's photo.

kim,seonggi
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Non-invasive perfusion MR imaging of the human brain via breath-holding

Cited 0 time in webofscience Cited 0 time in scopus
46 Viewed 0 Downloaded
Title
Non-invasive perfusion MR imaging of the human brain via breath-holding
Author(s)
Schulman, J.B.; Kashyap, S.; Seong Gi Kim; K. Uludag
Publication Date
2024-03
Journal
Scientific Reports, v.14, no.1
Publisher
Nature Publishing Group
Abstract
Dynamic susceptibility contrast (DSC) MRI plays a pivotal role in the accurate diagnosis and prognosis of several neurovascular diseases, but is limited by its reliance on gadolinium, an intravascularly injected chelated metal. Here, we determined the feasibility of measuring perfusion using a DSC analysis of breath-hold-induced gradient-echo-MRI signal changes. We acquired data at both 3 T and 7 T from ten healthy participants who engaged in eight consecutive breath-holds. By pairing a novel arterial input function strategy with a standard DSC MRI analysis, we measured the cerebral blood volume, flow, and transit delay, and found values to agree with those documented in the literature using gadolinium. We also observed voxel-wise agreement between breath-hold and arterial spin labeling measures of cerebral blood flow. Breath-holding resulted in significantly higher contrast-to-noise (6.2 at 3 T vs. 8.5 at 7 T) and gray matter-to-white matter contrast at higher field strength. Finally, using a simulation framework to assess the effect of dynamic vasodilation on perfusion estimation, we found global perfusion underestimation of 20–40%. For the first time, we have assessed the feasibility of and limitations associated with using breath-holds for perfusion estimation with DSC. We hope that the methods and results presented in this study will help pave the way toward contrast-free perfusion imaging, in both basic and clinical research. © The Author(s) 2024.
URI
https://pr.ibs.re.kr/handle/8788114/15183
DOI
10.1038/s41598-024-58086-8
ISSN
2045-2322
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse