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Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration

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Title
Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration
Author(s)
Won Gi Chung; Jiuk Jang; Gang Cui; Sanghoon Lee; Han Jeong; Haisu Kang; Hunkyu Seo; Sumin Kim; Enji Kim; Junwon Lee; Seung Geol Lee; Suk Ho Byeon; Jang-Ung Park
Publication Date
2024-05
Journal
Nature Nanotechnology, v.19, pp.688 - 697
Publisher
Nature Publishing Group
Abstract
Electronic retinal prostheses for stimulating retinal neurons are promising for vision restoration. However, the rigid electrodes of conventional retinal implants can inflict damage on the soft retina tissue. They also have limited selectivity due to their poor proximity to target cells in the degenerative retina. Here we present a soft artificial retina (thickness, 10 mu m) where flexible ultrathin photosensitive transistors are integrated with three-dimensional stimulation electrodes of eutectic gallium-indium alloy. Platinum nanoclusters locally coated only on the tip of these three-dimensional liquid-metal electrodes show advantages in reducing the impedance of the stimulation electrodes. These microelectrodes can enhance the proximity to the target retinal ganglion cells and provide effective charge injections (72.84 mC cm-2) to elicit neural responses in the retina. Their low Young's modulus (234 kPa), owing to their liquid form, can minimize damage to the retina. Furthermore, we used an unsupervised machine learning approach to effectively identify the evoked spikes to grade neural activities within the retinal ganglion cells. Results from in vivo experiments on a retinal degeneration mouse model reveal that the spatiotemporal distribution of neural responses on their retina can be mapped under selective localized illumination areas of light, suggesting the restoration of their vision. A soft artificial retina with flexible phototransistors and three-dimensional liquid-metal microelectrodes is used to enhance proximity to retinal ganglion cells and minimize damage to soft tissue as well as improve charge injection for vision restoration in retinal degenerative in vivo models.
URI
https://pr.ibs.re.kr/handle/8788114/15174
DOI
10.1038/s41565-023-01587-w
ISSN
1748-3387
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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