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Bioengineering toolkits for potentiating organoid therapeutics

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Title
Bioengineering toolkits for potentiating organoid therapeutics
Author(s)
Sewon Park; Seung-Woo Cho
Publication Date
2024-05
Journal
Advanced Drug Delivery Reviews, v.208
Publisher
Elsevier BV
Abstract
Organoids are three-dimensional, multicellular constructs that recapitulate the structural and functional features of specific organs. Because of these characteristics, organoids have been widely applied in biomedical research in recent decades. Remarkable advancements in organoid technology have positioned them as promising candidates for regenerative medicine. However, current organoids still have limitations, such as the absence of internal vasculature, limited functionality, and a small size that is not commensurate with that of actual organs. These limitations hinder their survival and regenerative effects after transplantation. Another significant concern is the reliance on mouse tumor-derived matrix in organoid culture, which is unsuitable for clinical translation due to its tumor origin and safety issues. Therefore, our aim is to describe engineering strategies and alternative biocompatible materials that can facilitate the practical applications of organoids in regenerative medicine. Furthermore, we highlight meaningful progress in organoid transplantation, with a particular emphasis on the functional restoration of various organs. © 2024 Elsevier B.V.
URI
https://pr.ibs.re.kr/handle/8788114/15026
DOI
10.1016/j.addr.2024.115238
ISSN
0169-409X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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