BROWSE

Related Scientist

cn's photo.

cn
나노의학연구단
more info

ITEM VIEW & DOWNLOAD

Endomysium-permeable muscle extracellular matrix composite hydrogel for promoting functional muscle recovery in muscle atrophy

Cited 0 time in webofscience Cited 0 time in scopus
67 Viewed 0 Downloaded
Title
Endomysium-permeable muscle extracellular matrix composite hydrogel for promoting functional muscle recovery in muscle atrophy
Author(s)
An, Soohwan; Jeon, Eun Je; Kim, Moohyun; Han, Seung Yeop; Song, Young Seok; Jeon, Jihoon; Jang-Ung Park; Seung-Woo Cho
Publication Date
2024-04
Journal
Chemical Engineering Journal, v.485
Publisher
Elsevier BV
Abstract
Sarcopenia is an age-related muscle atrophy that has recently been considered a significant factor in deteriorating the quality of life in elderly individuals. However, currently, there are no clinically-approved drugs available for the treatment of sarcopenia due to its complex etiology. Although cell therapies have been attempted to treat muscle atrophy, including sarcopenia, several problems still remain, including the cost and time for cell production, potential immunogenicity, and insufficient efficacy. In this sense, we suggest a cell-free therapeutic approach using a muscle extracellular matrix (MEM)-based composite hydrogel to boost proliferation and differentiation of endogenous cell populations by reconstituting the muscle-specific microenvironment. Here, we combine two components: (1) aldehyde-modified hyaluronic acid conjugated with the pyrogallol group (AH-PG), which enables permeation into the gaps among muscle fibers and in situ self-crosslinking of the hydrogel, and (2) decellularized muscle-derived MEM to provide muscle-specific components and growth factors for muscle restoration. The resultant composite hydrogel can be facilely injected via intramuscular route and stably maintained in the endomysial area where muscle stem cells reside, which changes the impaired atrophic and sarcopenic states to the muscle-regenerative microenvironment. As a result, the composite hydrogel promotes not only muscle mass recovery in disuse and age-induced muscle atrophies, but also muscle maturation accompanying vascularization and innervation, thereby significantly improving muscular function in sarcopenic animals. Together, our hybrid hydrogel can serve as a promising biomaterial for cell-free therapy of muscle atrophy. © 2024 Elsevier B.V.
URI
https://pr.ibs.re.kr/handle/8788114/15023
DOI
10.1016/j.cej.2024.149906
ISSN
1385-8947
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse