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Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging

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Title
Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging
Author(s)
Jin, Tao; Mehrens, Hunter; Hendrich, Kristy S.; Seong Gi Kim
Publication Date
2014-08
Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.34, no.8, pp.1402 - 1410
Publisher
NATURE PUBLISHING GROUP
Abstract
Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly mapped through the chemical exchange (CE) between glucose hydroxyl and water protons using CE-dependent saturation transfer (glucoCEST) magnetic resonance imaging (MRI). We propose an alternative technique—on-resonance CE-sensitive spin-lock (CESL) MRI—to enhance responses to glucose changes. Phantom data and simulations suggest higher sensitivity for this ‘glucoCESL’ technique (versus glucoCEST) in the intermediate CE regime relevant to glucose. Simulations of CESL signals also show insensitivity to B0-fluctuations. Several findings are apparent from in vivo glucoCESL studies of rat brain at 9.4 Tesla with intravenous injections. First, dose-dependent responses are nearly linearly for 0.25-, 0.5-, and 1-g/kg Glc administration (obtained with 12-second temporal resolution), with changes robustly detected for all doses. Second, responses at a matched dose of 1 g/kg are much larger and persist for a longer duration for 2DG versus Glc administration, and are minimal for mannitol as an osmolality control. And third, with similar increases in steadystate blood glucose levels, glucoCESL responses are B2.2 times higher for 2DG versus Glc, consistent with their different metabolic properties. Overall, we show that glucoCESL MRI could be a highly sensitive and quantifiable tool for glucose transport and metabolism studies.
URI
https://pr.ibs.re.kr/handle/8788114/1479
ISSN
0271-678X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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