BROWSE

Related Scientist

kim,seonggi's photo.

kim,seonggi
뇌과학이미징연구단
more info

ITEM VIEW & DOWNLOAD

Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging

Cited 56 time in webofscience Cited 55 time in scopus
1,306 Viewed 206 Downloaded
Title
Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging
Author(s)
Jin, Tao; Mehrens, Hunter; Hendrich, Kristy S.; Seong Gi Kim
Subject
CEST, ; chemical exchange, ; deoxyglucose, ; glucose metabolism, ; glucose transport
Publication Date
2014-08
Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.34, no.8, pp.1402 - 1410
Publisher
NATURE PUBLISHING GROUP
Abstract
Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly mapped through the chemical exchange (CE) between glucose hydroxyl and water protons using CE-dependent saturation transfer (glucoCEST) magnetic resonance imaging (MRI). We propose an alternative technique—on-resonance CE-sensitive spin-lock (CESL) MRI—to enhance responses to glucose changes. Phantom data and simulations suggest higher sensitivity for this ‘glucoCESL’ technique (versus glucoCEST) in the intermediate CE regime relevant to glucose. Simulations of CESL signals also show insensitivity to B0-fluctuations. Several findings are apparent from in vivo glucoCESL studies of rat brain at 9.4 Tesla with intravenous injections. First, dose-dependent responses are nearly linearly for 0.25-, 0.5-, and 1-g/kg Glc administration (obtained with 12-second temporal resolution), with changes robustly detected for all doses. Second, responses at a matched dose of 1 g/kg are much larger and persist for a longer duration for 2DG versus Glc administration, and are minimal for mannitol as an osmolality control. And third, with similar increases in steadystate blood glucose levels, glucoCESL responses are B2.2 times higher for 2DG versus Glc, consistent with their different metabolic properties. Overall, we show that glucoCESL MRI could be a highly sensitive and quantifiable tool for glucose transport and metabolism studies.
URI
https://pr.ibs.re.kr/handle/8788114/1479
DOI
10.1038/jcbfm.2014.97
ISSN
0271-678X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse