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식물노화·수명연구단
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Age-associated spinal stenosis in the turquoise killifish

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Title
Age-associated spinal stenosis in the turquoise killifish
Author(s)
Cho, Su-Hyeon; Seongsin Lee; Park, Jae-Il; La Yang, Yoon; Kim, Song-Rae; Ahn, Juhee; Jeong, Hoibin; Jung, Hye-Yeon; Nayoung Gwak; Kim, Kil-Nam; Yumi Kim
Publication Date
2023-10
Journal
iScience, v.26, no.10
Publisher
Elsevier Inc.
Abstract
Aging triggers spinal degeneration, including common spinal stenosis, which causes back and leg pain in older individuals, significantly impacting their quality of life. Here, we explored aging traits in turquoise killifish spines, potentially offering a model for age-linked spinal stenosis in humans. Aged turquoise killifish exhibited body shape deformation and increased vertebral collapse, which was further accelerated by spawning. High-resolution CT scans revealed suppressed cortical bone thickness and hemal arch area in vertebrae due to spawning, and osteophyte formation was observed in both aged and breeding fish populations. Scale mineralization mirrored these changes, increasing with age but being suppressed by spawning. The expression of sp7, sox9b, axin1, and wnt4a/b genes can be utilized to monitor age- and reproduction-dependent spine deformation. This study demonstrates that turquoise killifish and humans share certain phenotypes of age-related vertebral abnormalities, suggesting that turquoise killifish could serve as a potential model for studying human spinal stenosis. © 2023 The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/14651
DOI
10.1016/j.isci.2023.107877
ISSN
2589-0042
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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