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AlphaFold2 Can Predict Single-Mutation Effects

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Title
AlphaFold2 Can Predict Single-Mutation Effects
Author(s)
John M. Mcbride; Konstantin Polev; Abdirasulov, Amirbek; Vladimir Reinharz; Bartosz A. Grzybowski; Tsvi Tlusty
Publication Date
2023-11
Journal
Physical Review Letters, v.131, no.21
Publisher
American Physical Society
Abstract
AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations - as measured by the effective strain - is correlated across 3901 experimental and AF-predicted structures. Furthermore, analysis of ∼11 000 proteins shows that the local structural change correlates with various phenotypic changes. These findings suggest that AF can predict the range and magnitude of single-mutation effects on average, and we propose a method to improve precision of AF predictions and to indicate when predictions are unreliable. © 2023 American Physical Society.
URI
https://pr.ibs.re.kr/handle/8788114/14427
DOI
10.1103/PhysRevLett.131.218401
ISSN
0031-9007
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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