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GABAergic-like dopamine synapses in the brain

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Title
GABAergic-like dopamine synapses in the brain
Author(s)
Kim, Hyun-Jin; Hwang, Byungjae; Reva, Maria; Lee, Jieun; Lee, Byeong Eun; Lee, Youngeun; Cho, Eun Jeong; Jeong, Minseok; Lee, Seung Eun; Kyungjae Myung; Baik, Ja-Hyun; Park, Jung-Hoon; Kim, Jae-Ick
Publication Date
2023-10
Journal
Cell Reports, v.42, no.10
Publisher
Elsevier B.V.
Abstract
Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance, the true biological nature of dopamine synapses remains poorly understood. Here, we show that dopamine transmission is strongly correlated with GABA co-transmission across the brain and dopamine synapses are structured and function like GABAergic synapses with marked regional heterogeneity. In addition, GABAergic-like dopamine synapses are clustered on the dendrites, and GABA transmission at dopamine synapses has distinct physiological properties. Interestingly, the knockdown of neuroligin-2, a key postsynaptic protein at GABAergic synapses, unexpectedly does not weaken GABA co-transmission but instead facilitates it at dopamine synapses in the striatal neurons. More importantly, the attenuation of GABA co-transmission precedes deficits in dopaminergic transmission in animal models of Parkinson's disease. Our findings reveal the spatial and functional nature of GABAergic-like dopamine synapses in health and disease. © 2023 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/14259
DOI
10.1016/j.celrep.2023.113239
ISSN
2211-1247
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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