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USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes

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Title
USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes
Author(s)
Bin Lee; Young Hun Kim; Woori Lee; Hee Youn Choi; Jisun Lee; Jiwon Kim; Dương Ngọc Mai; Su Ful Jung; Man Sup Kwak; Jeon-Soo Shin
Publication Date
2023-11
Journal
Free Radical Biology and Medicine, v.208, pp.820 - 832
Publisher
Elsevier Inc.
Abstract
SQSTM1/p62 (sequestosome 1) is a multifunctional protein that serves as a receptor for selective autophagy and scaffold. In selective autophagy, p62 functions as a bridge between polyubiquitinated proteins and autophagosomes. Further, p62 acts as a signaling hub for many cellular pathways including mTORC1, NF-κB, and Keap1-Nrf2. Post-translational modifications of p62, such as ubiquitination and phosphorylation, are known to determine its binding partners and regulate their intracellular functions. However, the mechanism of p62 deubiquitination remains unclear. In this study, we found that ubiquitin-specific protease 13 (USP13), a member of the USP family, directly binds p62 and removes ubiquitin at Lys7 (K7) of the PB1 domain. USP13-mediated p62 deubiquitination enhances p62 protein stability and facilitates p62 oligomerization, resulting in increased autophagy and degradation of Keap1, which is a negative regulator of the antioxidant response that promotes Nrf2 activation. Thus, USP13 can be considered a therapeutic target as a deubiquitination enzyme of p62 in autophagy-related diseases. © 2023 The Authors
URI
https://pr.ibs.re.kr/handle/8788114/14017
DOI
10.1016/j.freeradbiomed.2023.09.024
ISSN
0891-5849
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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