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Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-Throughput Helicase Activity Assay Based on Graphene Oxide
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- Title
- Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High-Throughput Helicase Activity Assay Based on Graphene Oxide
- Author(s)
- Hongje Jang; Soo-Ryoon Ryoo; Young-Kwan Kim; Soojin Yoon; Henna Kim; Sang Woo Han; Byong-Seok Choi; Dong-Eun Kim; Dal-Hee Min
- Publication Date
- 2013-02
- Journal
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.52, no.8, pp.2340 - 2344
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- A GO-to solution: A simple graphene oxide (GO)-based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV helicase orthologous to the SARS CoV helicase. Some of these hits were validated using the same GO-based assay. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- ISSN
- 1433-7851
- Appears in Collections:
- Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
- Files in This Item:
- 2013-02-18-Angewandte Chemie-Discovery_of_Hepatitis_C.pdfDownload
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