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In situ biosensing technologies for an organ-on-a-chip

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Title
In situ biosensing technologies for an organ-on-a-chip
Author(s)
Jinyoung Kim; Junghoon Kim; Yoonhee Jin; Seung-Woo Cho
Publication Date
2023-10
Journal
BIOFABRICATION, v.15, no.4
Publisher
IOP Publishing Ltd
Abstract
The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges accompanying in vivo experiments. Organoids and organs-on-chips have been developed to model the in vitro, real-time biological and physiological features of organs. Numerous studies have deployed these systems to assess the in vitro, real-time responses of an organ to external stimuli. Particularly, organs-on-chips can be most efficiently employed in pharmaceutical drug development to predict the responses of organs before approving such drugs. Furthermore, multi-organ-on-a-chip systems facilitate the close representations of the in vivo environment. In this review, we discuss the biosensing technology that facilitates the in situ, real-time measurements of organ responses as readouts on organ-on-a-chip systems, including multi-organ models. Notably, a human-on-a-chip system integrated with automated multi-sensing will be established by further advancing the development of chips, as well as their assessment techniques.
URI
https://pr.ibs.re.kr/handle/8788114/13935
DOI
10.1088/1758-5090/aceaae
ISSN
1758-5082
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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