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복잡계자기조립연구단
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Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

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Title
Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker
Author(s)
Junseok Lee; Juhee Park; Kaushik Singha; Won Jong Kim
Subject
SURFACE FUNCTIONALIZATION,DELIVERY SYSTEM,HUMAN-CELLS,CARRIERS,THERAPY
Publication Date
2013-02
Journal
CHEMICAL COMMUNICATIONS, v.49, no.15, pp.1545 - 1547
Publisher
ROYAL SOC CHEMISTRY
Abstract
A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with long-wavelength light.
URI
https://pr.ibs.re.kr/handle/8788114/1391
DOI
10.1039/c2cc38510d
ISSN
1359-7345
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
2013-02-21-Chemical Communications-Mesoporous silica.pdfDownload

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