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KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

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Title
KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans
Author(s)
Choi, S.J.; Koh, J.-Y.; Rha, M.-S.; Seo, I.-H.; Hoyoung Lee; Jeong, S.; Park, S.-H.; Eui-Cheol Shin
Publication Date
2023-03
Journal
Cell Reports, v.42, no.3
Publisher
Elsevier B.V.
Abstract
Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In the present study, we examine the phenotypic and functional characteristics of KIR+CD8+ T cells and NKG2A+CD8+ T cells. KIRs and NKG2A tend to be expressed by human CD8+ T cells in a mutually exclusive manner. In addition, TCR clonotypes of KIR+CD8+ T cells barely overlap with those of NKG2A+CD8+ T cells, and KIR+CD8+ T cells are more terminally differentiated and replicative senescent than NKG2A+CD8+ T cells. Among cytokine receptors, IL12Rβ1, IL12Rβ2, and IL18Rβ are highly expressed by NKG2A+CD8+ T cells, whereas IL2Rβ is expressed by KIR+CD8+ T cells. IL-12/IL-18-induced production of IFN-γ is prominent in NKG2A+CD8+ T cells, whereas IL-15-induced NK-like cytotoxicity is prominent in KIR+CD8+ T cells. These findings suggest that KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations with different cytokine responsiveness. © 2023 The Author(s)
URI
https://pr.ibs.re.kr/handle/8788114/13835
DOI
10.1016/j.celrep.2023.112236
ISSN
2211-1247
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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