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KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

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dc.contributor.authorChoi, S.J.-
dc.contributor.authorKoh, J.-Y.-
dc.contributor.authorRha, M.-S.-
dc.contributor.authorSeo, I.-H.-
dc.contributor.authorHoyoung Lee-
dc.contributor.authorJeong, S.-
dc.contributor.authorPark, S.-H.-
dc.contributor.authorEui-Cheol Shin-
dc.date.accessioned2023-08-25T22:01:33Z-
dc.date.available2023-08-25T22:01:33Z-
dc.date.created2023-04-03-
dc.date.issued2023-03-
dc.identifier.issn2211-1247-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13835-
dc.description.abstractSubsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In the present study, we examine the phenotypic and functional characteristics of KIR+CD8+ T cells and NKG2A+CD8+ T cells. KIRs and NKG2A tend to be expressed by human CD8+ T cells in a mutually exclusive manner. In addition, TCR clonotypes of KIR+CD8+ T cells barely overlap with those of NKG2A+CD8+ T cells, and KIR+CD8+ T cells are more terminally differentiated and replicative senescent than NKG2A+CD8+ T cells. Among cytokine receptors, IL12Rβ1, IL12Rβ2, and IL18Rβ are highly expressed by NKG2A+CD8+ T cells, whereas IL2Rβ is expressed by KIR+CD8+ T cells. IL-12/IL-18-induced production of IFN-γ is prominent in NKG2A+CD8+ T cells, whereas IL-15-induced NK-like cytotoxicity is prominent in KIR+CD8+ T cells. These findings suggest that KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations with different cytokine responsiveness. © 2023 The Author(s)-
dc.language영어-
dc.publisherElsevier B.V.-
dc.titleKIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000962510200001-
dc.identifier.scopusid2-s2.0-85149718040-
dc.identifier.rimsid80364-
dc.contributor.affiliatedAuthorHoyoung Lee-
dc.contributor.affiliatedAuthorEui-Cheol Shin-
dc.identifier.doi10.1016/j.celrep.2023.112236-
dc.identifier.bibliographicCitationCell Reports, v.42, no.3-
dc.relation.isPartOfCell Reports-
dc.citation.titleCell Reports-
dc.citation.volume42-
dc.citation.number3-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusCD8(+) T-CELLS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusSENESCENCE-
dc.subject.keywordPlusPACKAGE-
dc.subject.keywordAuthorKIR-
dc.subject.keywordAuthorNKG2A-
dc.subject.keywordAuthorvirtual memory T cells-
dc.subject.keywordAuthorCD8+ T cells-
dc.subject.keywordAuthorCP: Immunology-
dc.subject.keywordAuthorinnate-like T cells-
dc.subject.keywordAuthorkiller immunoglobulin-like receptor-
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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