BROWSE

Related Scientist

cmsd's photo.

cmsd
분자분광학및동력학연구단
more info

ITEM VIEW & DOWNLOAD

Two Opposing Effects of Monovalent Cations on the Stability of i-Motif Structure

Cited 0 time in webofscience Cited 0 time in scopus
181 Viewed 0 Downloaded
Title
Two Opposing Effects of Monovalent Cations on the Stability of i-Motif Structure
Author(s)
Sung Eun Kim; Seok-Cheol Hong
Publication Date
2023-02
Journal
JOURNAL OF PHYSICAL CHEMISTRY B, v.127, no.9, pp.1932 - 1939
Publisher
AMER CHEMICAL SOC
Abstract
At acidic pH, cytosine-rich single-stranded DNA can be folded into a tetraplex structure called i-motif (iM). In recent studies, the effect of monovalent cations on the stability of iM structure has been addressed, but a consensus about the issue has not been reached yet. Thus, we investigated the effects of various factors on the stability of iM structure using fluorescence resonance energy transfer (FRET)-based analysis for three types of iM derived from human telomere sequences. We confirmed that the protonated cytosine-cytosine (C:C+) base pair is destabilized as the concentration of monovalent cations (Li+, Na+, K+) increases and that Li+ has the greatest tendency of destabilization. Intriguingly, monovalent cations would play an ambivalent role in iM formation by making single-stranded DNA flexible and pliant for an iM structure. In particular, we found that Li+ has a notably greater flexibilizing effect than Na(+ )and K+. All taken together, we conclude that the stability of iM structure is controlled by the subtle balance of the two counteractive effects of monovalent cations: electrostatic screening and disruption of cytosine base pairing. (GRAPHICS)
URI
https://pr.ibs.re.kr/handle/8788114/13741
DOI
10.1021/acs.jpcb.2c07069
ISSN
1520-6106
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse