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Ferritin Nanoshuttle for Long-Lasting Self-Healing of Phenolic Hydrogels

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Title
Ferritin Nanoshuttle for Long-Lasting Self-Healing of Phenolic Hydrogels
Author(s)
Jisoo Shin; Soohwan An; Soojeong Choi; Mikyung Shin; Jung Seung Lee; Jung Ho Cho; Haeshin Lee; Seung-Woo Cho
Publication Date
2023-06
Journal
NANO LETTERS, v.23, no.13, pp.5934 - 5942
Publisher
AMER CHEMICAL SOC
Abstract
Herein,we highlight a novel finding that ferritin can play a crucialrole in the "self-healing lifetime" of soft phenolicmaterials. Ferritin interacts with a catechol-functionalized polymerto form a self-healable and adhesive hydrogel bidirectionally by providingand retrieving Fe3+. As a result of its unique role asa nanoshuttle to store and release iron, ferritin significantly increasesthe self-healing lifetime of the hydrogel compared with that affordedby catechol-Fe3+ coordination through direct Fe3+ addition without ferritin. Ferritin also induces stableoxidative coupling between catechol moieties following metal coordination,which contributes to double cross-linking networks of catechol-catecholadducts and catechol-Fe3+ coordination. Thus, ferritin-mediatedcross-linking can provide phenolic hydrogels with the advantages ofhydrogels prepared by both metal coordination and oxidative coupling,thereby overcoming the limitations of the current cross-linking methodsof phenolic hydrogels and broadening their versatility in biomedicalapplications.
URI
https://pr.ibs.re.kr/handle/8788114/13646
DOI
10.1021/acs.nanolett.3c00903
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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