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Mucoadhesive Phenolic Pectin Hydrogels for Saliva Substitute and Oral Patch

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Title
Mucoadhesive Phenolic Pectin Hydrogels for Saliva Substitute and Oral Patch
Author(s)
Soojeong Choi; Jihoon Jeon; Yunsu Bae; Yongsoon Hwang; Seung-Woo Cho
Publication Date
2023-10
Journal
Advanced Functional Materials, v.33, no.44
Publisher
John Wiley & Sons Ltd.
Abstract
Oral disease is one of the most common conditions worldwide, negatively affecting general health, reducing the quality of life, and often developing into systemic illness. However, the design of therapeutic agents for oral diseases is challenging due to various unique features of the oral cavity, including its wet and dynamic environment and curved shape. Herein, the development of highly biocompatible mucoadhesive functional hydrogels for oral applications is reported, generated by introducing bio-inspired phenolic moieties into a pectin polymer. Pyrogallol-functionalized pectin (Pec-PG) can be crosslinked in situ via autoxidation without chemical agents and readily fabricated as various formulations. Sprayable Pec-PG hydrogel exhibits strong mucoadhesion and outstanding hydration ability ex vivo and in vivo, thus displaying significant potential as a novel saliva substitute for dry mouth. The authors further show that topical application of mucoadhesive Pec-PG patches pre-loaded with corticosteroid significantly promotes the repair of diabetic oral ulcer tissue via prolonged drug release, free radical scavenging, and physical barrier effects. Moreover, similar applications for oral ulcer treatment using a pectin hydrogel modified with catechol (Pec-CA), another phenolic moiety are demonstrated. Together, these findings suggest that mucoadhesive phenolic pectin derivatives can provide highly biocompatible, convenient, and effective hydrogel platforms for treating oral diseases. © 2023 Wiley-VCH GmbH.
URI
https://pr.ibs.re.kr/handle/8788114/13575
DOI
10.1002/adfm.202303043
ISSN
1616-301X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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