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Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions

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Title
Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions
Author(s)
Jonathan Sabate Del Rio; Jooyoung Ro; Yoon Heejeong; Park Tae-Eun; Yoon-Kyoung Cho
Publication Date
2023-03
Journal
Biosensors and Bioelectronics, v.224
Publisher
Elsevier Ltd
Abstract
Organs-on-chips (OoCs) are biomimetic in vitro systems based on microfluidic cell cultures that recapitulate the in vivo physicochemical microenvironments and the physiologies and key functional units of specific human organs. These systems are versatile and can be customized to investigate organ-specific physiology, pathology, or pharmacology. They are more physiologically relevant than traditional two-dimensional cultures, can potentially replace the animal models or reduce the use of these models, and represent a unique opportunity for the development of personalized medicine when combined with human induced pluripotent stem cells. Continuous monitoring of important quality parameters of OoCs via a label-free, non-destructive, reliable, high-throughput, and multiplex method is critical for assessing the conditions of these systems and generating relevant analytical data; moreover, elaboration of quality predictive models is required for clinical trials of OoCs. Presently, these analytical data are obtained by manual or automatic sampling and analyzed using single-point, off-chip traditional methods. In this review, we describe recent efforts to integrate biosensing technologies into OoCs for monitoring the physiologies, functions, and physicochemical microenvironments of OoCs. Furthermore, we present potential alternative solutions to current challenges and future directions for the application of artificial intelligence in the development of OoCs and cyber-physical systems. These “smart” OoCs can learn and make autonomous decisions for process optimization, self-regulation, and data analysis. © 2023 Elsevier B.V.
URI
https://pr.ibs.re.kr/handle/8788114/13537
DOI
10.1016/j.bios.2022.115057
ISSN
0956-5663
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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