BROWSE

Related Scientist

cn's photo.

cn
나노의학연구단
more info

ITEM VIEW & DOWNLOAD

Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo

Cited 0 time in webofscience Cited 0 time in scopus
170 Viewed 0 Downloaded
Title
Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling In Vivo
Author(s)
Sumin Jeong; Wookjin Shin; Mansoo Park; Jung-Uk Lee; Yongjun Lim; Kunwoo Noh; Jae-Hyun Lee; Young-Wook Jun; Minsuk Kwak; Jinwoo Cheon
Publication Date
2023-05
Journal
Nano Letters, v.23, no.11, pp.5227 - 5235
Publisher
American Chemical Society
Abstract
As a new enabling nanotechnology tool for wireless, target-specific, and long-distance stimulation of mechanoreceptors in vivo, here we present a hydrogel magnetomechanical actuator (h-MMA) nanoparticle. To allow both deep-tissue penetration of input signals and efficient force generation, h-MMA integrates a two-step transduction mechanism that converts magnetic anisotropic energy to thermal energy within its magnetic core (i.e., Zn0.4Fe2.6O4 nanoparticle cluster) and then to mechanical energy to induce the surrounding polymer (i.e., pNiPMAm) shell contraction, finally delivering forces to activate targeted mechanoreceptors. We show that h-MMAs enable on-demand modulation of Notch signaling in both fluorescence reporter cell lines and a xenograft mouse model, demonstrating its utility as a powerful in vivo perturbation approach for mechanobiology interrogation in a minimally invasive and untethered manner. © 2023 American Chemical Society.
URI
https://pr.ibs.re.kr/handle/8788114/13494
DOI
10.1021/acs.nanolett.3c01207
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse