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Seizure-induced neutrophil adhesion in brain capillaries leads to a decrease in postictal cerebral blood flow

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Title
Seizure-induced neutrophil adhesion in brain capillaries leads to a decrease in postictal cerebral blood flow
Author(s)
Hyun-Kyoung Lim; Bae, S.; Kayoung Han; Kang, B.-M.; Yoonyi Jeong; Seong-Gi Kim; Minah Suh
Publication Date
2023-05
Journal
iScience, v.26, no.5
Publisher
Elsevier Inc.
Abstract
Cerebral hypoperfusion has been proposed as a potential cause of postictal neurological dysfunction in epilepsy, but its underlying mechanism is still unclear. We show that a 30% reduction in postictal cerebral blood flow (CBF) has two contributing factors: the early hypoperfusion up to ∼30 min post-seizure was mainly induced by arteriolar constriction, while the hypoperfusion that persisted for over an hour was due to increased capillary stalling induced by neutrophil adhesion to brain capillaries, decreased red blood cell (RBC) flow accompanied by constriction of capillaries and venules, and elevated intercellular adhesion molecule-1 (ICAM-1) expression. Administration of antibodies against the neutrophil marker Ly6G and against LFA-1, which mediates adhesive interactions with ICAM-1, prevented neutrophil adhesion and recovered the prolonged CBF reductions to control levels. Our findings provide evidence that seizure-induced neutrophil adhesion to cerebral microvessels via ICAM-1 leads to prolonged postictal hypoperfusion, which may underlie neurological dysfunction in epilepsy.
URI
https://pr.ibs.re.kr/handle/8788114/13317
DOI
10.1016/j.isci.2023.106655
ISSN
2589-0042
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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