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Seizure-induced neutrophil adhesion in brain capillaries leads to a decrease in postictal cerebral blood flow

DC Field Value Language
dc.contributor.authorHyun-Kyoung Lim-
dc.contributor.authorBae, S.-
dc.contributor.authorKayoung Han-
dc.contributor.authorKang, B.-M.-
dc.contributor.authorYoonyi Jeong-
dc.contributor.authorSeong-Gi Kim-
dc.contributor.authorMinah Suh-
dc.date.accessioned2023-05-04T22:00:23Z-
dc.date.available2023-05-04T22:00:23Z-
dc.date.created2023-05-02-
dc.date.issued2023-05-
dc.identifier.issn2589-0042-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13317-
dc.description.abstractCerebral hypoperfusion has been proposed as a potential cause of postictal neurological dysfunction in epilepsy, but its underlying mechanism is still unclear. We show that a 30% reduction in postictal cerebral blood flow (CBF) has two contributing factors: the early hypoperfusion up to ∼30 min post-seizure was mainly induced by arteriolar constriction, while the hypoperfusion that persisted for over an hour was due to increased capillary stalling induced by neutrophil adhesion to brain capillaries, decreased red blood cell (RBC) flow accompanied by constriction of capillaries and venules, and elevated intercellular adhesion molecule-1 (ICAM-1) expression. Administration of antibodies against the neutrophil marker Ly6G and against LFA-1, which mediates adhesive interactions with ICAM-1, prevented neutrophil adhesion and recovered the prolonged CBF reductions to control levels. Our findings provide evidence that seizure-induced neutrophil adhesion to cerebral microvessels via ICAM-1 leads to prolonged postictal hypoperfusion, which may underlie neurological dysfunction in epilepsy.-
dc.language영어-
dc.publisherElsevier Inc.-
dc.titleSeizure-induced neutrophil adhesion in brain capillaries leads to a decrease in postictal cerebral blood flow-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001001118900001-
dc.identifier.scopusid2-s2.0-85153206049-
dc.identifier.rimsid80649-
dc.contributor.affiliatedAuthorHyun-Kyoung Lim-
dc.contributor.affiliatedAuthorKayoung Han-
dc.contributor.affiliatedAuthorYoonyi Jeong-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.contributor.affiliatedAuthorMinah Suh-
dc.identifier.doi10.1016/j.isci.2023.106655-
dc.identifier.bibliographicCitationiScience, v.26, no.5-
dc.relation.isPartOfiScience-
dc.citation.titleiScience-
dc.citation.volume26-
dc.citation.number5-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusEPILEPTIC SEIZURES-
dc.subject.keywordPlusPERFUSION-
dc.subject.keywordPlusHYPOPERFUSION-
dc.subject.keywordPlusBARRIER-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusRECRUITMENT-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCYTOKINES-
dc.subject.keywordPlusLFA-1-
dc.subject.keywordPlusMAC-1-
dc.subject.keywordAuthorBiological sciences-
dc.subject.keywordAuthorNeuroanatomy-
dc.subject.keywordAuthorNeuroscience-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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