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Selective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production

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Title
Selective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production
Author(s)
Sanghyun Lee; Jaewon Song; Sungchul Kim; Jongkyu Kim; Yujin Hong; Youngkyun Kim; Donghyun Kim; Daehyun Baek; Kwangseog Ahn
Publication Date
2013-06
Journal
CELL HOST & MICROBE, v.13, no.6, pp.678 - 690
Publisher
CELL PRESS
Abstract
Virulence of human cytomegalovirus (HCMV) clinical isolates correlates with carriage of a 15 kb segment in the UL/b0 region of the viral genome, which is absent from attenuated strains. The mechanisms by which this segment contributes to HCMV virulence remain obscure. We observed that intergenic RNA sequences within the 15 kb segment function as a microRNA (miRNA) decay element (miRDE) and direct the selective, sequence-specific turnover of mature miR-17 and miR-20a encoded within the host miR-17-92 cluster. Unlike canonical miRNAmRNA interactions, the miRNA-miRDE interactions did not repress miRDE expression. miRNA binding site mutations retargeted miRDE to other miR-17-92 cluster miRNAs, which are otherwise resistant to miRDE-mediated decay. miRDE function was required to accelerate virus production in the context of lytic HCMV infection. These results indicate a role for viral noncoding RNA in regulating cellular miRNAs during HCMV pathogenesis and suggest that noncoding RNAs may play a role in mature miRNA turnover.
URI
https://pr.ibs.re.kr/handle/8788114/1320
ISSN
1931-3128
Appears in Collections:
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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