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RNA 연구단
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Selective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production

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dc.contributor.authorSanghyun Lee-
dc.contributor.authorJaewon Song-
dc.contributor.authorSungchul Kim-
dc.contributor.authorJongkyu Kim-
dc.contributor.authorYujin Hong-
dc.contributor.authorYoungkyun Kim-
dc.contributor.authorDonghyun Kim-
dc.contributor.authorDaehyun Baek-
dc.contributor.authorKwangseog Ahn-
dc.date.available2015-04-20T06:58:13Z-
dc.date.created2014-08-11-
dc.date.issued2013-06-
dc.identifier.issn1931-3128-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1320-
dc.description.abstractVirulence of human cytomegalovirus (HCMV) clinical isolates correlates with carriage of a 15 kb segment in the UL/b0 region of the viral genome, which is absent from attenuated strains. The mechanisms by which this segment contributes to HCMV virulence remain obscure. We observed that intergenic RNA sequences within the 15 kb segment function as a microRNA (miRNA) decay element (miRDE) and direct the selective, sequence-specific turnover of mature miR-17 and miR-20a encoded within the host miR-17-92 cluster. Unlike canonical miRNAmRNA interactions, the miRNA-miRDE interactions did not repress miRDE expression. miRNA binding site mutations retargeted miRDE to other miR-17-92 cluster miRNAs, which are otherwise resistant to miRDE-mediated decay. miRDE function was required to accelerate virus production in the context of lytic HCMV infection. These results indicate a role for viral noncoding RNA in regulating cellular miRNAs during HCMV pathogenesis and suggest that noncoding RNAs may play a role in mature miRNA turnover.-
dc.languageENG-
dc.publisherCELL PRESS-
dc.titleSelective Degradation of Host MicroRNAs by an Intergenic HCMV Noncoding RNA Accelerates Virus Production-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000330851000008-
dc.identifier.scopusid2-s2.0-84879126123-
dc.description.wostc33-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.contributor.affiliatedAuthorJongkyu Kim-
dc.identifier.bibliographicCitationCELL HOST & MICROBE, v.13, no.6, pp.678 - 690-
dc.description.scptc33-
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Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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