BROWSE

Related Scientist

cn's photo.

cn
나노의학연구단
more info

ITEM VIEW & DOWNLOAD

Ligand Coupling and Decoupling Modulates Stem Cell Fate

Cited 0 time in webofscience Cited 0 time in scopus
158 Viewed 0 Downloaded
Title
Ligand Coupling and Decoupling Modulates Stem Cell Fate
Author(s)
Ramar Thangam; Seong Yeol Kim; Nayeon Kang; Hyunsik Hong; Hyun-Jeong Lee; Sungkyu Lee; Daun Jeong; Kyong-Ryol Tag; Kanghyeon Kim; Yangzhi Zhu; Wujin Sun; Han-Jun Kim; Seung-Woo Cho; Jae-Pyoung Ahn; Woo Young Jang; Jong Seung Kim; Ramasamy Paulmurugan; Ali Khademhosseini; Hong-Kyu Kim; Heemin Kang
Publication Date
2023-02
Journal
ADVANCED FUNCTIONAL MATERIALS, v.33, no.8
Publisher
WILEY-V C H VERLAG GMBH
Abstract
In natural microenvironment, various proteins containing adhesive ligands in fibrous and non-fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein, materials presenting movably couplable ligands are developed by grafting liganded gold nanoparticles (AuNPs) to a substrate followed by flexibly grafting liganded movable linear nanomaterials (MLNs) to the substrate via a long bendable linker, thereby creating a space between the MLNs and the AuNPs in the decoupled state. Magnetic control of the MLNs decreases this space via the bending of the linker to couple the MLNs to the AuNPs. Remote control of ligand coupling stimulates integrin recruitment to the coupled ligands, thereby non-toxically facilitating the focal adhesion, mechanosensing, and potential differentiation of stem cells, which is suppressed by ligand decoupling. Versatile tuning of size, aspect ratio, distributions, and ligands of the MLNs can help to decipher dynamic ligand-coupling-dependent stem cell fate to advance regenerative therapies.
URI
https://pr.ibs.re.kr/handle/8788114/13137
DOI
10.1002/adfm.202206673
ISSN
1616-301X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse