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A heterologous AZD1222 priming and BNT162b2 boosting regimen more efficiently elicits neutralizing antibodies, but not memory T cells, than the homologous BNT162b2 regimen

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Title
A heterologous AZD1222 priming and BNT162b2 boosting regimen more efficiently elicits neutralizing antibodies, but not memory T cells, than the homologous BNT162b2 regimen
Author(s)
Yae Jee Baek; Woo-Joong Kim; Jae-Hoon Ko; Youn-Jung Lee; Jin Young Ahn; Jung Ho Kim; Ho Cheol Jang; Hye Won Jeong; Yong Chan Kim; Yoon Soo Park; Sung-Han Kim; Kyong Ran Peck; Eui Cheol Shin; Jun Yong Choi
Publication Date
2023-03
Journal
Vaccine, v.41, no.10, pp.1694 - 1702
Publisher
Elsevier BV
Abstract
Background: Comparative analyses of SARS-CoV-2-specific immune responses elicited by diverse primeboost regimens are required to establish efficient regimens for the control of COVID-19. Method: In this prospective observational cohort study, spike-specific immunoglobulin G (IgG) and neutralizing antibodies (nAbs) alongside spike-specific T-cell responses in age-matched groups of homologous BNT162b2/BNT162b2 or AZD1222/AZD1222 vaccination, heterologous AZD1222/BNT162b2 vaccination, and prior wild-type SARS-CoV-2 infection/vaccination were evaluated. Results: Peak immune responses were achieved after the second vaccine dose in the naïve vaccinated groups and after the first dose in the prior infection/vaccination group. Peak titers of anti-spike IgG and nAb were significantly higher in the AZD1222/BNT162b2 vaccination and prior infection/vaccination groups than in the BNT162b2/BNT162b2 or AZD1222/AZD1222 groups. However, the frequency of interferon-c-producing CD4+ T cells was highest in the BNT162b2/BNT162b2 vaccination group. Similar results were observed in the analysis of polyfunctional T cells. When nAb and CD4+ T-cell responses against the Delta variant were analyzed, the prior infection/vaccination group exhibited higher responses than the groups of other homologous or heterologous vaccination regimens. Conclusion: nAbs are efficiently elicited by heterologous AZD1222/BNT162b2 vaccination, as well as prior infection/vaccination, whereas spike-specific CD4+ T-cell responses are efficiently elicited by homologous BNT162b2 vaccination. Variant-recognizing immunity is more efficiently generated by prior infection/- vaccination than the other homologous or heterologous vaccination regimens.
URI
https://pr.ibs.re.kr/handle/8788114/13097
DOI
10.1016/j.vaccine.2023.01.063
ISSN
0264-410X
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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