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A heterologous AZD1222 priming and BNT162b2 boosting regimen more efficiently elicits neutralizing antibodies, but not memory T cells, than the homologous BNT162b2 regimen

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dc.contributor.authorYae Jee Baek-
dc.contributor.authorWoo-Joong Kim-
dc.contributor.authorJae-Hoon Ko-
dc.contributor.authorYoun-Jung Lee-
dc.contributor.authorJin Young Ahn-
dc.contributor.authorJung Ho Kim-
dc.contributor.authorHo Cheol Jang-
dc.contributor.authorHye Won Jeong-
dc.contributor.authorYong Chan Kim-
dc.contributor.authorYoon Soo Park-
dc.contributor.authorSung-Han Kim-
dc.contributor.authorKyong Ran Peck-
dc.contributor.authorEui Cheol Shin-
dc.contributor.authorJun Yong Choi-
dc.date.accessioned2023-04-04T22:03:17Z-
dc.date.available2023-04-04T22:03:17Z-
dc.date.created2023-03-14-
dc.date.issued2023-03-
dc.identifier.issn0264-410X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13097-
dc.description.abstractBackground: Comparative analyses of SARS-CoV-2-specific immune responses elicited by diverse primeboost regimens are required to establish efficient regimens for the control of COVID-19. Method: In this prospective observational cohort study, spike-specific immunoglobulin G (IgG) and neutralizing antibodies (nAbs) alongside spike-specific T-cell responses in age-matched groups of homologous BNT162b2/BNT162b2 or AZD1222/AZD1222 vaccination, heterologous AZD1222/BNT162b2 vaccination, and prior wild-type SARS-CoV-2 infection/vaccination were evaluated. Results: Peak immune responses were achieved after the second vaccine dose in the naïve vaccinated groups and after the first dose in the prior infection/vaccination group. Peak titers of anti-spike IgG and nAb were significantly higher in the AZD1222/BNT162b2 vaccination and prior infection/vaccination groups than in the BNT162b2/BNT162b2 or AZD1222/AZD1222 groups. However, the frequency of interferon-c-producing CD4+ T cells was highest in the BNT162b2/BNT162b2 vaccination group. Similar results were observed in the analysis of polyfunctional T cells. When nAb and CD4+ T-cell responses against the Delta variant were analyzed, the prior infection/vaccination group exhibited higher responses than the groups of other homologous or heterologous vaccination regimens. Conclusion: nAbs are efficiently elicited by heterologous AZD1222/BNT162b2 vaccination, as well as prior infection/vaccination, whereas spike-specific CD4+ T-cell responses are efficiently elicited by homologous BNT162b2 vaccination. Variant-recognizing immunity is more efficiently generated by prior infection/- vaccination than the other homologous or heterologous vaccination regimens.-
dc.language영어-
dc.publisherElsevier BV-
dc.titleA heterologous AZD1222 priming and BNT162b2 boosting regimen more efficiently elicits neutralizing antibodies, but not memory T cells, than the homologous BNT162b2 regimen-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000952367800001-
dc.identifier.scopusid2-s2.0-85149175286-
dc.identifier.rimsid80226-
dc.contributor.affiliatedAuthorEui Cheol Shin-
dc.identifier.doi10.1016/j.vaccine.2023.01.063-
dc.identifier.bibliographicCitationVaccine, v.41, no.10, pp.1694 - 1702-
dc.relation.isPartOfVaccine-
dc.citation.titleVaccine-
dc.citation.volume41-
dc.citation.number10-
dc.citation.startPage1694-
dc.citation.endPage1702-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordAuthorSARS-CoV-2-
dc.subject.keywordAuthorVaccine-
dc.subject.keywordAuthorHeterologous vaccination-
dc.subject.keywordAuthorHybrid immunity-
dc.subject.keywordAuthorNeutralizing antibody-
dc.subject.keywordAuthorT cell-
Appears in Collections:
Korea Virus Research Institute(한국바이러스기초연구소) > Center for Viral Immunology(바이러스 면역 연구센터) > 1. Journal Papers (저널논문)
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