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복잡계자기조립연구단
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TRPV4 regulates mitochondrial Ca2+-status and physiology in primary murine T cells based on their immunological state

DC Field Value Language
dc.contributor.authorAcharya, T.K.-
dc.contributor.authorKumar, S.-
dc.contributor.authorRokade, T.P.-
dc.contributor.authorYoung Tae Chang-
dc.contributor.authorGoswami, C.-
dc.date.accessioned2023-04-04T22:00:38Z-
dc.date.available2023-04-04T22:00:38Z-
dc.date.created2023-03-06-
dc.date.issued2023-04-
dc.identifier.issn0024-3205-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13073-
dc.description.abstractT cell activation process is critically affected by temperature and intracellular Ca2+-signalling. Yet, the nature and the key molecules involved in such complex Ca2+-signalling is poorly understood. It is mostly assumed that ion channels present in the plasma membrane primarily regulate the cytosolic Ca2+-levels exclusively. TRPV4 is a non-selective Ca2+ channel which can be activated at physiological temperature. TRPV4 is involved in several physiological, pathophysiological process as well as different forms of pain. Here we demonstrate that TRPV4 is endogenously expressed in T cell and is present in the mitochondria of T cells. TRPV4 activation increases mitochondrial Ca2+-levels, and alters mitochondrial temperature as well as specific metabolisms. The TRPV4-dependent increment in the mitochondrial Ca2+ is context-dependent and not just passively due to the increment in the cytosolic Ca2+. Our work also indicates that mitochondrial Ca2+-level correlates positively with a series of essential factors, such as mitochondrial membrane potential, mitochondrial ATP production and negatively correlates with certain factors such as mitochondrial temperature. We propose that TRPV4-mediated mitochondrial Ca2+-signalling and other metabolisms has implications in the immune activation process including immune synapse formation. Our data also endorse the re-evaluation of Ca2+-signalling in T cell, especially in the light of mitochondrial Ca2+-buffering and in higher body temperature, such as in case of fever. Presence of TRPV4 in the mitochondria of T cell is relevant for proper and optimum immune response and may provide evolutionary adaptive benefit. These findings may also have broad implications in different pathophysiological process, neuro-immune cross-talks, and channelopathies involving TRPV4. © 2023 Elsevier Inc.-
dc.language영어-
dc.publisherElsevier Inc.-
dc.titleTRPV4 regulates mitochondrial Ca2+-status and physiology in primary murine T cells based on their immunological state-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000944784900001-
dc.identifier.scopusid2-s2.0-85148354583-
dc.identifier.rimsid80048-
dc.contributor.affiliatedAuthorYoung Tae Chang-
dc.identifier.doi10.1016/j.lfs.2023.121493-
dc.identifier.bibliographicCitationLife Sciences, v.318-
dc.relation.isPartOfLife Sciences-
dc.citation.titleLife Sciences-
dc.citation.volume318-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusCOMPLEX II-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCARDIOLIPIN-
dc.subject.keywordPlusCALCIUM-
dc.subject.keywordPlusCHANNEL-
dc.subject.keywordPlusATP-
dc.subject.keywordAuthorATP-
dc.subject.keywordAuthorCa2+-
dc.subject.keywordAuthorCardiolipin-
dc.subject.keywordAuthorER-mito contact sites-
dc.subject.keywordAuthorMembrane potential-
dc.subject.keywordAuthorMitochondria-
dc.subject.keywordAuthorPain-
dc.subject.keywordAuthorT cell-
dc.subject.keywordAuthorTCR activation-
dc.subject.keywordAuthorTemperature-
dc.subject.keywordAuthorTRPV4-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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