T-type Ca2+ channels in normal and abnormal brain functions.

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Title
T-type Ca2+ channels in normal and abnormal brain functions.
Author(s)
Eunji Cheong; Hee-Sup Shin
Publication Date
2013-07
Journal
PHYSIOLOGICAL REVIEWS, v.93, no.3, pp.961 - 992
Publisher
AMER PHYSIOLOGICAL SOC
Abstract
Low-voltage- activated T-type Ca2 channels are widely expressed in various types of neurons. Once deinactivated by hyperpolarization, T-type channels are ready to be activated by a small depolarization near the resting membrane potential and, therefore, are optimal for regulating the excitability and electroresponsiveness of neurons under physiological conditions near resting states. Ca2 influx through T-type channels engenders low-threshold Ca2 spikes, which in turn trigger a burst of action potentials. Low-threshold burst firing has been implicated in the synchronization of the thalamocortical circuit during sleep and in absence seizures. It also has been suggested that T-type channels play an important role in pain signal transmission, based on their abundant expression in pain-processing pathways in peripheral and central neurons. In this review, we will describe studies on the role of T-type Ca2 channels in the physiological as well as pathological generation of brain rhythms in sleep, absence epilepsy, and pain signal transmission. Recent advances in studies of T-type channels in the control of cognition will also be briefly discussed.
URI
https://pr.ibs.re.kr/handle/8788114/1303
ISSN
0031-9333
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
2013-07-01-Physiol_T-type_reivew.pdfDownload

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