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Local Drug Delivery Strategies for Glioblastoma Treatment

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Title
Local Drug Delivery Strategies for Glioblastoma Treatment
Author(s)
Gi Doo Cha; Sonwoo Jung; Seung Hong Choi; Dae-Hyeong Kim
Publication Date
2022-07
Journal
Brain Tumor Research and Treatment, v.10, no.3, pp.151 - 157
Publisher
대한뇌종양학회
Abstract
Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the lim- ited efficacy of standard treatment is the high recurrence rate of GBM, even after surgical resection. Hence, intensive postsurgical chemical therapies, such as the systemic delivery of various drugs and/ or drug combinations, are typically followed after surgery. However, overcoming the blood-brain barrier by systemic administration to efficiently deliver drugs to the brain tumor remains a daunting goal. There- fore, various local drug delivery methods showing potential for improved therapeutic efficacy have been proposed. In particular, the recent application of electronic devices for the controlled delivery of che- motherapy drugs to GBM tissue has attracted attention. We herein review the recent progress of local drug delivery strategies, including electronics-assisted strategies, at the research and commercial level. We also present a brief discussion of the unsolved challenges and future research direction of localized chemotherapy methods for GBM.
URI
https://pr.ibs.re.kr/handle/8788114/12777
DOI
10.14791/btrt.2022.0017
ISSN
2288-2405
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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