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Lee, Jun Seok
복잡계 자기조립 연구단
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Doxorubicin/ce6-loaded nanoparticle coated with polymer via singlet oxygen-sensitive linker for photodynamically assisted chemotherapy

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Title
Doxorubicin/ce6-loaded nanoparticle coated with polymer via singlet oxygen-sensitive linker for photodynamically assisted chemotherapy
Author(s)
Junseok Lee; Lee, Y.M.; Jinhwan Kim; Won Jong Kim
Publication Date
2017-05
Journal
Nanotheranostics, v.1, no.2, pp.196 - 207
Publisher
Ivyspring International Publisher
Abstract
It is widely known that the therapeutic effect of nanoparticle-based chemotherapeutics could be greatly enhanced by the introduction of the photodynamic effect. Herein we report a chlorin e6-incorporated mesoporous silica nanoparticles (MSNs) covered with a polyethylene glycol shell conjugated via a singlet oxygen-sensitive labile bis(alkylthio)alkene linker (CeAP-L-PEG). In this study, single irradiation with biocompatible red light induced both intracellular doxorubicin release and photochemical internalization, and consequently enhanced anti-cancer effect was observed in vitro and in vivo. This study suggests the potential of our precisely designed nanoparticle system for photodynamically assisted chemotherapy. © Ivyspring International Publisher.
URI
https://pr.ibs.re.kr/handle/8788114/12181
DOI
10.7150/ntno.18576
ISSN
2206-7418
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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