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복잡계 자기조립 연구단
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Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells

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Title
Mechanism assay of interaction between blood vessels-near infrared probe and cell surface marker proteins of endothelial cells
Author(s)
Abdul Sisak, Muhammad Asri; Louis, Fiona; Miyao, Tomoyuki; Lee, Sun Hyeok; Chang, Young-Tae; Matsusaki, Michiya
Publication Date
2022-06
Journal
Materials Today Bio, v.15
Publisher
Elsevier B.V.
Abstract
© 2022 The AuthorsIn vivo blood vessels imaging is crucial to study blood vessels related diseases in real-time. For this purpose, fluorescent based imaging is one of the utmost techniques for imaging a living system. The discovery of a new near-infrared probe (CyA-B2) by screening chemical probe library in our previous report which showed the most specific binding on the blood capillaries of the 3D-tissue models give us interest to study more about the binding site of this probe to the surface of endothelial cells main component cell of blood capillaries. By studying the competition assays of CyA-B2 using several potential surface markers of endothelial cells found through the chemical database (ChEMBL) and manually selected, CD133 gave the lowest IC50 (half maximal inhibitory concentration) value. Hence, CD133 protein which is expressed on the endothelial cell membrane was postulated to be the binding site due to the suppression of CyA-B2 on the blood capillaries by the competition assays. Since, CD133 is also expressed on many types of cancer cells, it would be useful to use CyA-B2 as a bioprobe to monitor or diagnostic tumor growth.
URI
https://pr.ibs.re.kr/handle/8788114/12150
DOI
10.1016/j.mtbio.2022.100332
ISSN
2590-0064
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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