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Enhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction

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dc.contributor.authorSagang Koo-
dc.contributor.authorOk Kyu Park-
dc.contributor.authorJonghoon Kim-
dc.contributor.authorSang Ihn Han-
dc.contributor.authorTae Yong Yoo-
dc.contributor.authorNohyun Lee-
dc.contributor.authorYoung Geon Kim-
dc.contributor.authorHyunjoong Kim-
dc.contributor.authorChaehong Lim-
dc.contributor.authorBae, Jong-Seong-
dc.contributor.authorYoo, Jin-
dc.contributor.authorDokyoon Kim-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorTaeghwan Hyeon-
dc.date.accessioned2022-07-29T07:48:35Z-
dc.date.available2022-07-29T07:48:35Z-
dc.date.created2022-02-21-
dc.date.issued2022-02-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12056-
dc.description.abstract© An urgent need in chemodynamic therapy (CDT) is to achieve high Fenton catalytic efficiency at small doses of CDT agents. However, simple general promotion of the Fenton reaction increases the risk of damaging normal cells along with the cancer cells. Therefore, a tailored strategy to selectively enhance the Fenton reactivity in tumors, for example, by taking advantage of the characteristics of the tumor microenvironment (TME), is in high demand. Herein, a heterogeneous CDT system based on copper-iron peroxide nanoparticles (CFp NPs) is designed for TME-mediated synergistic therapy. CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger portions at lower oxidation states, cooperatively facilitate hydroxyl radical production through a highly efficient catalytic loop to achieve an excellent tumor therapeutic efficacy. This is distinct from previous heterogeneous CDT systems in that the synergism is closely coupled with the Cu+-assisted conversion of Fe3+ to Fe2+ rather than their independent actions. As a result, almost complete ablation of tumors at a minimal treatment dose is demonstrated without the aid of any other therapeutic modality. Furthermore, CFp NPs generate O2 during the catalysis and exhibit a TME-responsive T1 magnetic resonance imaging contrast enhancement, which are useful for alleviating hypoxia and in vivo monitoring of tumors, respectively.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleEnhanced Chemodynamic Therapy by Cu-Fe Peroxide Nanoparticles: Tumor Microenvironment-Mediated Synergistic Fenton Reaction-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000776691400071-
dc.identifier.scopusid2-s2.0-85124168731-
dc.identifier.rimsid77754-
dc.contributor.affiliatedAuthorSagang Koo-
dc.contributor.affiliatedAuthorOk Kyu Park-
dc.contributor.affiliatedAuthorJonghoon Kim-
dc.contributor.affiliatedAuthorSang Ihn Han-
dc.contributor.affiliatedAuthorTae Yong Yoo-
dc.contributor.affiliatedAuthorNohyun Lee-
dc.contributor.affiliatedAuthorYoung Geon Kim-
dc.contributor.affiliatedAuthorHyunjoong Kim-
dc.contributor.affiliatedAuthorChaehong Lim-
dc.contributor.affiliatedAuthorDokyoon Kim-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.identifier.doi10.1021/acsnano.1c09171-
dc.identifier.bibliographicCitationACS Nano, v.16, no.2, pp.2535 - 2545-
dc.relation.isPartOfACS Nano-
dc.citation.titleACS Nano-
dc.citation.volume16-
dc.citation.number2-
dc.citation.startPage2535-
dc.citation.endPage2545-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusMETAL-ORGANIC FRAMEWORKS-
dc.subject.keywordPlusIRON-OXIDE NANOPARTICLES-
dc.subject.keywordPlusMAGNETIC NANOPARTICLES-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusOXYGEN-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusCONTRAST-
dc.subject.keywordPlusHYPOXIA-
dc.subject.keywordPlusOXIDATION-
dc.subject.keywordPlusCATALYST-
dc.subject.keywordAuthorantitumor agents-
dc.subject.keywordAuthorcancer-
dc.subject.keywordAuthorchemodynamic therapy-
dc.subject.keywordAuthorFenton reaction-
dc.subject.keywordAuthorhypoxia-
dc.subject.keywordAuthortumor microenvironment-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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