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Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance

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Title
Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance
Author(s)
Jeong-Yun Lee; Taeyi You; Choong-Hee Lee; Geun Ho Im; Heewon Seo; Choong-Wan Woo; Seong-Gi Kim
Publication Date
2022-07
Journal
Current Biology, v.32, no.13, pp.2834 - 2847
Publisher
Cell Press
Abstract
Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optogenetics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability. © 2022 Elsevier Inc.
URI
https://pr.ibs.re.kr/handle/8788114/12003
DOI
10.1016/j.cub.2022.04.090
ISSN
0960-9822
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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