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Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance

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dc.contributor.authorJeong-Yun Lee-
dc.contributor.authorTaeyi You-
dc.contributor.authorChoong-Hee Lee-
dc.contributor.authorGeun Ho Im-
dc.contributor.authorHeewon Seo-
dc.contributor.authorChoong-Wan Woo-
dc.contributor.authorSeong-Gi Kim-
dc.date.accessioned2022-07-29T07:42:02Z-
dc.date.available2022-07-29T07:42:02Z-
dc.date.created2022-07-22-
dc.date.issued2022-07-
dc.identifier.issn0960-9822-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12003-
dc.description.abstractAlthough pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optogenetics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability. © 2022 Elsevier Inc.-
dc.language영어-
dc.publisherCell Press-
dc.titleRole of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000833979900017-
dc.identifier.scopusid2-s2.0-85133561849-
dc.identifier.rimsid78522-
dc.contributor.affiliatedAuthorJeong-Yun Lee-
dc.contributor.affiliatedAuthorTaeyi You-
dc.contributor.affiliatedAuthorChoong-Hee Lee-
dc.contributor.affiliatedAuthorGeun Ho Im-
dc.contributor.affiliatedAuthorHeewon Seo-
dc.contributor.affiliatedAuthorChoong-Wan Woo-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.identifier.doi10.1016/j.cub.2022.04.090-
dc.identifier.bibliographicCitationCurrent Biology, v.32, no.13, pp.2834 - 2847-
dc.relation.isPartOfCurrent Biology-
dc.citation.titleCurrent Biology-
dc.citation.volume32-
dc.citation.number13-
dc.citation.startPage2834-
dc.citation.endPage2847-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusDESCENDING FACILITATORY MODULATION-
dc.subject.keywordPlusPREDICTION ERRORS-
dc.subject.keywordPlusNEUROPATHIC PAIN-
dc.subject.keywordPlusFEAR-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusNUCLEUS-
dc.subject.keywordPlusSIGNALS-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusSTIMULATION-
dc.subject.keywordAuthorofMRI-
dc.subject.keywordAuthoractive defensive response-
dc.subject.keywordAuthoroptogenetic functional magnetic resonance imaging-
dc.subject.keywordAuthorPAG-
dc.subject.keywordAuthorpain-
dc.subject.keywordAuthorperiaqueductal gray-
dc.subject.keywordAuthorACC-
dc.subject.keywordAuthoranterior cingulate cortex-
dc.subject.keywordAuthorfear-
dc.subject.keywordAuthorfear-avoidance model-
dc.subject.keywordAuthormouse fMRI-
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Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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