Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance
DC Field | Value | Language |
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dc.contributor.author | Jeong-Yun Lee | - |
dc.contributor.author | Taeyi You | - |
dc.contributor.author | Choong-Hee Lee | - |
dc.contributor.author | Geun Ho Im | - |
dc.contributor.author | Heewon Seo | - |
dc.contributor.author | Choong-Wan Woo | - |
dc.contributor.author | Seong-Gi Kim | - |
dc.date.accessioned | 2022-07-29T07:42:02Z | - |
dc.date.available | 2022-07-29T07:42:02Z | - |
dc.date.created | 2022-07-22 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/12003 | - |
dc.description.abstract | Although pain-related excessive fear is known to be a key factor in chronic pain disability, which involves the anterior cingulate cortex (ACC), little is known about the downstream circuits of the ACC for fear avoidance in pain processing. Using behavioral experiments and functional magnetic resonance imaging with optogenetics at 15.2 T, we demonstrate that the ACC is a part of the abnormal circuit changes in chronic pain and its downstream circuits are closely related to modulating sensorimotor integration and generating active movement rather than carrying sensory information. The projection from the ACC to the dorsolateral and lateral parts of the periaqueductal gray (dl/lPAG) especially enhances both reflexive and active avoidance behavior toward pain. Collectively, our results indicate that increased signals from the ACC to the dl/lPAG might be critical for excessive fear avoidance in chronic pain disability. © 2022 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000833979900017 | - |
dc.identifier.scopusid | 2-s2.0-85133561849 | - |
dc.identifier.rimsid | 78522 | - |
dc.contributor.affiliatedAuthor | Jeong-Yun Lee | - |
dc.contributor.affiliatedAuthor | Taeyi You | - |
dc.contributor.affiliatedAuthor | Choong-Hee Lee | - |
dc.contributor.affiliatedAuthor | Geun Ho Im | - |
dc.contributor.affiliatedAuthor | Heewon Seo | - |
dc.contributor.affiliatedAuthor | Choong-Wan Woo | - |
dc.contributor.affiliatedAuthor | Seong-Gi Kim | - |
dc.identifier.doi | 10.1016/j.cub.2022.04.090 | - |
dc.identifier.bibliographicCitation | Current Biology, v.32, no.13, pp.2834 - 2847 | - |
dc.relation.isPartOf | Current Biology | - |
dc.citation.title | Current Biology | - |
dc.citation.volume | 32 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 2834 | - |
dc.citation.endPage | 2847 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DESCENDING FACILITATORY MODULATION | - |
dc.subject.keywordPlus | PREDICTION ERRORS | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.subject.keywordPlus | FEAR | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordAuthor | ofMRI | - |
dc.subject.keywordAuthor | active defensive response | - |
dc.subject.keywordAuthor | optogenetic functional magnetic resonance imaging | - |
dc.subject.keywordAuthor | PAG | - |
dc.subject.keywordAuthor | pain | - |
dc.subject.keywordAuthor | periaqueductal gray | - |
dc.subject.keywordAuthor | ACC | - |
dc.subject.keywordAuthor | anterior cingulate cortex | - |
dc.subject.keywordAuthor | fear | - |
dc.subject.keywordAuthor | fear-avoidance model | - |
dc.subject.keywordAuthor | mouse fMRI | - |