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복잡계자기조립연구단
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DNA-templated silver nanoclusters as label-free, sensitive detection probes for potassium ions and nitric oxide

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dc.contributor.authorJihyun Lee-
dc.contributor.authorJunghong Park-
dc.contributor.authorHong Hee Lee-
dc.contributor.authorHugh I. Kim-
dc.contributor.authorWon Jong Kim-
dc.date.available2015-04-20T06:28:11Z-
dc.date.created2014-11-21-
dc.date.issued2014-05-
dc.identifier.issn2050-750X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1184-
dc.description.abstractDNA-templated silver nanoclusters (DNA–AgNCs) have emerged as promising materials for sensing, biolabelling, and bio-imaging due to their fluorogenic properties. Using the 12 mer DNA with a cytosine-rich sequence, AgCNs have been formed successfully. Herein, we develop two different types of DNA–AgNC systems for the detection of potassium ions (K+) and nitric oxide (NO) by utilizing the structural change of DNA or DNA template transformation. In K+ detection, a thrombin binding aptamer (TBA) was utilized as both the AgNC template and the K+ binding probe. The fluorescence emission of the DNA1–AgNC probe was diminished proportionally to the amount of K+ detected, which transforms the AgNC-adapted structure into G-quadruplex. On the other hand, NO detection has been accomplished by NO-induced deamination of cytosine. The structural change of cytosine to deoxyuridine destabilizes the DNA2–AgNC structure, resulting in quenching of fluorescence intensity. The characteristics of these two highly quantitative detection probes were analysed by UV absorption, fluorescence emission, and transmission electron microscopy (TEM). Each system provides a detection limit of 6.2 mM for K+ and 0.1 mM for NO. We expect that these systems enable the opening of a new horizon for highly sensitive and selective detection systems.-
dc.description.uri1-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleDNA-templated silver nanoclusters as label-free, sensitive detection probes for potassium ions and nitric oxide-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000334121500029-
dc.identifier.scopusid2-s2.0-84898071728-
dc.identifier.rimsid16530ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJihyun Lee-
dc.contributor.affiliatedAuthorJunghong Park-
dc.contributor.affiliatedAuthorWon Jong Kim-
dc.identifier.doi10.1039/c3tb21446j-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS CHEMISTRY B, v.2, no.17, pp.2616 - 2621-
dc.citation.titleJOURNAL OF MATERIALS CHEMISTRY B-
dc.citation.volume2-
dc.citation.number17-
dc.citation.startPage2616-
dc.citation.endPage2621-
dc.date.scptcdate2018-10-01-
dc.description.wostc16-
dc.description.scptc16-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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