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나노물질 및 화학반응 연구단
나노물질 및 화학반응 연구단
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Electrical biomolecule detection using nanopatterned silicon via block copolymer lithography

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Title
Electrical biomolecule detection using nanopatterned silicon via block copolymer lithography
Author(s)
Jeong C.K.; Hyeong Min Jin; Ahn J.-H.; Park T.J.; Yoo H.G.; Koo M.; Choi Y.-K.; Sang Ouk Kim; Keon Jae Lee
Publication Date
2014-01
Journal
SMALL, v.10, no.2, pp.337 - 343
Publisher
WILEY-V C H VERLAG GMBH
Abstract
An electrical biosensor exploiting a nanostructured semiconductor is a promising technology for the highly sensitive, label-free detection of biomolecules via a straightforward electronic signal. The facile and scalable production of a nanopatterned electrical silicon biosensor by block copolymer (BCP) nanolithography is reported. A cost-effective and large-area nanofabrication, based on BCP self-assembly and single-step dry etching, is developed for the hexagonal nanohole patterning of thin silicon films. The resultant nanopatterned electrical channel modified with biotin molecules successfully detects the two proteins, streptavidin and avidin, down to nanoscale molarities (≈1 nm). The nanoscale pattern comparable to the Debye screening length and the large surface area of the three-dimensional silicon nanochannel enable excellent sensitivity and stability. A device simulation confirms that the nanopatterned structure used in this work is effective for biomolecule detection. This approach relying on the scalable self-assembly principle offers a high-throughput manufacturing process for clinical lab-on-a-chip diagnoses and relevant biomolecular studies. A nanopatterned silicon electrical biosensor is fabricated by block copolymer lithography and used for the detection of model proteins down to nanoscale molarities (≈1 nm). The nanoscale patterned silicon electrical channel enables the biosensor to realize excellent sensitivity and stability. A simulation is performed to demonstrate that the nanopatterned structure is effective for biomolecule detection. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI
https://pr.ibs.re.kr/handle/8788114/1149
ISSN
1613-6810
Appears in Collections:
Center for Nanomaterials and Chemical Reactions(나노물질 및 화학반응 연구단) > Journal Papers (저널논문)
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