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Basic Principles and Clinical Applications of CRISPR-Based Genome Editing

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Title
Basic Principles and Clinical Applications of CRISPR-Based Genome Editing
Author(s)
Jung Min Lim; Hyongbum Henry Kim
Publication Date
2022-02
Journal
YONSEI MEDICAL JOURNAL, v.63, no.2, pp.105 - 113
Publisher
YONSEI UNIV COLL MEDICINE
Abstract
Advances in sequencing technologies have facilitated the discovery of previously unknown genetic variants in both inherited and acquired disorders, and tools to correct these pathogenic variants are rapidly evolving. Since the first introduction of CRISPR-Cas9 in 2012, the field of CRISPR-based genome editing has progressed immensely, giving hope to many patients suffering from genetic disorders that lack effective treatment. In this review, we will examine the basic principles of CRISPR-based genome editing, explain the mechanisms of new genome editors, including base editors and prime editors, and evaluate the therapeutic possibilities of CRISPR-based genome editing by focusing on recently published clinical trials and animal studies. Although efficacy and safety issues remain a large concern, we cannot deny that CRISPR-based genome editing will soon be prevalent in clinical practice.
URI
https://pr.ibs.re.kr/handle/8788114/11368
DOI
10.3349/ymj.2022.63.2.105
ISSN
0513-5796
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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