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Hyperthermia Effect of Nanoclusters Governed by Interparticle Crystalline Structures

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Title
Hyperthermia Effect of Nanoclusters Governed by Interparticle Crystalline Structures
Author(s)
Miseon Jeong; Sanghoon Lee; Dae Young Song; Sunghwi Kang; Tae-Hyun Shin; Jin-sil Choi
Publication Date
2021-11-23
Journal
ACS Omega, v.6, no.46, pp.31161 - 31167
Publisher
American Chemical Society
Abstract
© 2021 The Authors. Published by American Chemical Society.Magnetic nanoparticles have an important role as heat generators in magnetic fluid hyperthermia, a type of next-generation cancer treatment. Despite various trials to improve the heat generation capability of magnetic nanoparticles, iron oxide nanoparticles are the only approved heat generators for clinical applications, which require a large injection dose due to their low hyperthermia efficiency. In this study, iron oxide nanoclusters (NCs) with a highly enhanced hyperthermia effect and adjustable size were synthesized through a facile and simple solvothermal method. Among the samples, the NCs with a size of 25 nm showed the highest hyperthermia efficiency. Differently sized NCs exhibit inconsistent interparticle crystalline alignments, which affect their magnetic properties (e.g., coercivity and saturation magnetization). As a result, the optimal NCs exhibited a significantly enhanced heat generation efficiency compared with that of isolated iron oxide nanoparticles (ca. 7 nm), and their hyperthermia effect on skin cancer cells was confirmed.
URI
https://pr.ibs.re.kr/handle/8788114/11065
DOI
10.1021/acsomega.1c04632
ISSN
2470-1343
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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