Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

Abstract

© 2021 American Chemical Society.We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.