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Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging

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Title
Iron Oxide-Coated Dextran Nanoparticles with Efficient Renal Clearance for Musculoskeletal Magnetic Resonance Imaging
Author(s)
Ji-wook Kim; Jiyong Cheong; Hayeon Cheong; Jun Geol Yoon; Joon-Yong Jung; Jae-Hyun Lee; Tae-Hyun Shin
Publication Date
2021-12-24
Journal
ACS Applied Nano Materials, v.4, no.12, pp.12943 - 12948
Publisher
American Chemical Society
Abstract
© 2021 American Chemical Society.We report that inverted iron oxide nanoparticles (i-IONPs) have great potential for musculoskeletal imaging, which is one of the fastest-growing fields in MRI. Upon intra-articular injection, i-IONPs provide positive T1 values and decent soft tissue contrast effects, allowing a clear visualization of complex anatomical details of the joint. i-IONPs show substantially stronger and longer-lasting T1 contrast effects than clinical gadolinium-based contrast agents. In addition, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from body through a renal clearance route.
URI
https://pr.ibs.re.kr/handle/8788114/11063
DOI
10.1021/acsanm.1c03470
ISSN
2574-0970
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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