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유전체 항상성 연구단
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Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

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Title
Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes
Author(s)
Apelt, Katja; Lans, Hannes; Orlando D. Schärer; Luijsterburg, Martijn S.
Publication Date
2021-12
Journal
Cellular and Molecular Life Sciences, v.78, no.24, pp.7925 - 7942
Publisher
Springer Science and Business Media Deutschland GmbH
Abstract
© 2021, The Author(s).Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as well as on chromatin containing DNA lesions. The choreography between XPC and DDB2, their interconnection with post-translational modifications such as ubiquitylation, SUMOylation, methylation, poly(ADP-ribos)ylation, acetylation, and the functional links with chromatin remodelling activities regulate not only the initial recognition of DNA lesions in nucleosomes, but also the downstream recruitment and necessary displacement of GG-NER factors as repair progresses. In this review, we highlight how nucleotide excision repair leaves a mark on chromatin to enable DNA damage detection in nucleosomes.
URI
https://pr.ibs.re.kr/handle/8788114/10913
DOI
10.1007/s00018-021-03984-7
ISSN
1420-682X
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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