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유전체 항상성 연구단
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Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

DC Field Value Language
dc.contributor.authorApelt, Katja-
dc.contributor.authorLans, Hannes-
dc.contributor.authorOrlando D. Schärer-
dc.contributor.authorLuijsterburg, Martijn S.-
dc.date.accessioned2021-12-22T01:30:00Z-
dc.date.available2021-12-22T01:30:00Z-
dc.date.created2021-12-15-
dc.date.issued2021-12-
dc.identifier.issn1420-682X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10913-
dc.description.abstract© 2021, The Author(s).Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as well as on chromatin containing DNA lesions. The choreography between XPC and DDB2, their interconnection with post-translational modifications such as ubiquitylation, SUMOylation, methylation, poly(ADP-ribos)ylation, acetylation, and the functional links with chromatin remodelling activities regulate not only the initial recognition of DNA lesions in nucleosomes, but also the downstream recruitment and necessary displacement of GG-NER factors as repair progresses. In this review, we highlight how nucleotide excision repair leaves a mark on chromatin to enable DNA damage detection in nucleosomes.-
dc.language영어-
dc.publisherSpringer Science and Business Media Deutschland GmbH-
dc.titleNucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000714327500005-
dc.identifier.scopusid2-s2.0-85118544465-
dc.identifier.rimsid76841-
dc.contributor.affiliatedAuthorOrlando D. Schärer-
dc.identifier.doi10.1007/s00018-021-03984-7-
dc.identifier.bibliographicCitationCellular and Molecular Life Sciences, v.78, no.24, pp.7925 - 7942-
dc.relation.isPartOfCellular and Molecular Life Sciences-
dc.citation.titleCellular and Molecular Life Sciences-
dc.citation.volume78-
dc.citation.number24-
dc.citation.startPage7925-
dc.citation.endPage7942-
dc.type.docTypeReview-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusUV-INDUCED UBIQUITYLATION-
dc.subject.keywordPlusUBIQUITIN LIGASE-
dc.subject.keywordPlusREMODELING COMPLEX-
dc.subject.keywordPlusHISTONE H3-
dc.subject.keywordPlusCELLULAR-RESPONSE-
dc.subject.keywordPlusBINDING-PROTEIN-
dc.subject.keywordPlusH2AX PHOSPHORYLATION-
dc.subject.keywordPlusDISTINCT ROLES-
dc.subject.keywordPlusXPC PROTEIN-
dc.subject.keywordPlusP48 SUBUNIT-
dc.subject.keywordAuthorChromatin-
dc.subject.keywordAuthorDDB2-
dc.subject.keywordAuthorNucleotide excision repair-
dc.subject.keywordAuthorPost-translational modification-
dc.subject.keywordAuthorPTM-
dc.subject.keywordAuthorXPC-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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