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복잡계 자기조립 연구단
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Neutrophil-Selective Fluorescent Probe Development through Metabolism-Oriented Live-Cell Distinction

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Title
Neutrophil-Selective Fluorescent Probe Development through Metabolism-Oriented Live-Cell Distinction
Author(s)
Min Gao; Sun Hyeok Lee; Park, Sang Hyuk; Larissa Miasiro Ciaramicoli; Haw-Young Kwon; Heewon Cho; Jeong, Joseph; Young-Tae Chang
Publication Date
2021-10-25
Journal
Angewandte Chemie - International Edition, v.60, no.44, pp.23743 - 23749
Publisher
John Wiley and Sons Inc
Abstract
© 2021 Wiley-VCH GmbHHuman neutrophils are the most abundant leukocytes and have been considered as the first line of defence in the innate immune system. Selective imaging of live neutrophils will facilitate the in situ study of neutrophils in infection or inflammation events as well as clinical diagnosis. However, small-molecule-based probes for the discrimination of live neutrophils among different granulocytes in human blood have yet to be reported. Herein, we report the first fluorescent probe NeutropG for the specific distinction and imaging of active neutrophils. The selective staining mechanism of NeutropG is elucidated as metabolism-oriented live-cell distinction (MOLD) through lipid droplet biogenesis with the help of ACSL and DGAT. Finally, NeutropG is applied to accurately quantify neutrophil levels in fresh blood samples by showing a high correlation with the current clinical method.
URI
https://pr.ibs.re.kr/handle/8788114/10810
DOI
10.1002/anie.202108536
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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