BROWSE

Related Scientist

NANOMAT's photo.

NANOMAT
나노입자 연구단
more info

ITEM VIEW & DOWNLOAD

Prediction of prognosis in glioblastoma using radiomics features of dynamic contrast-enhanced mri

DC Field Value Language
dc.contributor.authorPak, Elena-
dc.contributor.authorChoi, Kyu Sung-
dc.contributor.authorSeung Hong Choi-
dc.contributor.authorPark, Chul-Kee-
dc.contributor.authorKim, Tae Min-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorLee, Joo Ho-
dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorHwang, Inpyeong-
dc.contributor.authorYoo, Roh-Eul-
dc.contributor.authorKang, Koung Mi-
dc.contributor.authorYun, Tae Jin-
dc.contributor.authorKim, Ji-Hoon-
dc.contributor.authorSohn, Chul-Ho-
dc.date.accessioned2021-12-08T06:50:08Z-
dc.date.available2021-12-08T06:50:08Z-
dc.date.created2021-09-27-
dc.date.issued2021-09-
dc.identifier.issn1229-6929-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10804-
dc.description.abstract© 2021 The Korean Society of Radiology.Objective: To develop a radiomics risk score based on dynamic contrast-enhanced (DCE) MRI for prognosis prediction in patients with glioblastoma. Materials and Methods: One hundred and fifty patients (92 male [61.3%]; mean age ± standard deviation, 60.5 ± 13.5 years) with glioblastoma who underwent preoperative MRI were enrolled in the study. Six hundred and forty-two radiomic features were extracted from volume transfer constant (Ktrans), fractional volume of vascular plasma space (Vp), and fractional volume of extravascular extracellular space (Ve) maps of DCE MRI, wherein the regions of interest were based on both T1-weighted contrast-enhancing areas and non-enhancing T2 hyperintense areas. Using feature selection algorithms, salient radiomic features were selected from the 642 features. Next, a radiomics risk score was developed using a weighted combination of the selected features in the discovery set (n = 105); the risk score was validated in the validation set (n = 45) by investigating the difference in prognosis between the “radiomics risk score” groups. Finally, multivariable Cox regression analysis for progression-free survival was performed using the radiomics risk score and clinical variables as covariates. Results: 16 radiomic features obtained from non-enhancing T2 hyperintense areas were selected among the 642 features identified. The radiomics risk score was used to stratify high-and low-risk groups in both the discovery and validation sets (both p < 0.001 by the log-rank test). The radiomics risk score and presence of isocitrate dehydrogenase (IDH) mutation showed independent associations with progression-free survival in opposite directions (hazard ratio, 3.56; p = 0.004 and hazard ratio, 0.34; p = 0.022, respectively). Conclusion: We developed and validated the “radiomics risk score” from the features of DCE MRI based on non-enhancing T2 hyperintense areas for risk stratification of patients with glioblastoma. It was associated with progression-free survival independently of IDH mutation status.-
dc.language영어-
dc.publisherKorean Radiological Society-
dc.titlePrediction of prognosis in glioblastoma using radiomics features of dynamic contrast-enhanced mri-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000691895500008-
dc.identifier.scopusid2-s2.0-85115165902-
dc.identifier.rimsid76425-
dc.contributor.affiliatedAuthorSeung Hong Choi-
dc.identifier.doi10.3348/kjr.2020.1433-
dc.identifier.bibliographicCitationKorean Journal of Radiology, v.22, no.9, pp.1514 - 1524-
dc.relation.isPartOfKorean Journal of Radiology-
dc.citation.titleKorean Journal of Radiology-
dc.citation.volume22-
dc.citation.number9-
dc.citation.startPage1514-
dc.citation.endPage1524-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.subject.keywordPlusSIGNAL-INTENSITY LESIONS-
dc.subject.keywordPlusSTANDARD TREATMENT-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusDIMENSIONALITY-
dc.subject.keywordPlusTEMOZOLOMIDE-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordAuthorDynamic contrast enhanced MRI-
dc.subject.keywordAuthorGlioblastoma-
dc.subject.keywordAuthorKtrans-
dc.subject.keywordAuthorProgression-
dc.subject.keywordAuthorRadiomics-
dc.subject.keywordAuthorVe-
dc.subject.keywordAuthorVp-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse