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Kim, Chi-Ju
첨단연성물질 연구단
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Fully automated light transmission aggregometry on a disc for platelet function tests

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Title
Fully automated light transmission aggregometry on a disc for platelet function tests
Author(s)
Chi-Ju Kim; Jungmin Kim; Jonathan Sabaté del Río; Dong Yeob Ki; Junyoung Kim; Yoon-Kyoung Cho
Publication Date
2021-11-25
Journal
LAB ON A CHIP, v.21, no.23, pp.4707 - 4715
Publisher
ROYAL SOC CHEMISTRY
Abstract
Platelet function tests, a group of assays that measure the ability of platelets to aggregate and promote clotting in a sample of blood, are performed in various medical fields to assess inherited platelet function disorders and monitor antiplatelet therapies. Light transmission aggregometry (LTA) is considered the gold standard for platelet function assessment. However, the lack of a standardized protocol is a major drawback when applied at the point of care. Moreover, it is a time-consuming and labor-intensive assay that requires a large volume of blood. Here, we describe the design, fabrication, and operation of a centrifugal microfluidic disc that can perform a fully automated LTA assay from a small volume of a whole blood sample (<1 mL), achieving highly reproducible results (3.2% coefficient of variation) within a short period (<25 min). The assays performed with this device yield more precise and accurate results than traditional LTA because of the automation of the reaction steps, minimal human operation, robust detection strategy via the distinctive structure of the microfluidic chamber, and quick analysis that minimizes the adverse effects of platelet instability.
URI
https://pr.ibs.re.kr/handle/8788114/10748
DOI
10.1039/d1lc00708d
ISSN
1473-0197
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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